"Completely different from other antibiotic compounds currently on the market, PMX-30063 is a synthetic chemical mimic of host defense proteins, one of the oldest and most effective antimicrobial defense systems found in virtually all living creatures.
Host defense proteins are part of the non-humoral (that is, not involving antibodies) response that keep humans from rapidly succumbing to infections. Biologists have discovered many different classes of natural host-defense peptides. Although these molecules possess a diverse array of structures, their physicochemical properties are similar."
Innate immunity is an ancient but responsive host defence against bacterial infection. In addition to preventing infections from gaining a foothold, the host defence proteins also appears to prime the immune system in the event that the infection is too severe.
As compared to antibiotics, this new antimicrobial has unique characteristics:
- disrupts bacterial cell membranes in a way that reduces bacterial resistance
- effective against Gram-positive and Gram-negative bacteria
- kills rather than affecting reproduction
- fast acting
- effective against bacteria that are resistant to antibiotics